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A molecular genetic linkage map of mouse chromosome 13 anchored by the beige ( bg ) and satin ( sa ) loci

Identifieur interne : 000A83 ( Main/Exploration ); précédent : 000A82; suivant : 000A84

A molecular genetic linkage map of mouse chromosome 13 anchored by the beige ( bg ) and satin ( sa ) loci

Auteurs : Monica J. Justice [États-Unis] ; Colleen M. Silan [États-Unis] ; Jeffrey D. Ceci [États-Unis] ; Arthur M. Buchberg [États-Unis] ; Neal G. Copeland [États-Unis] ; Nancy A. Jenkins [États-Unis]

Source :

RBID : ISTEX:F5FC42B44354615038549A605956B64C1AFFAF27

English descriptors

Abstract

Abstract: A molecular genetic linkage map of mouse chromosome 13 was constructed using cloned DNA markers and interspecific backcross mice from two independent crosses. The map locations of Ctla-3, Dhfr, Fim-1, 4 12, Hexb, Hilda, Inhba, Lamb-1.13, Ral, Rrm2-ps3, and Tcrg were determined with respect to the beige (bg) and satin (sa) loci. The map locations of these genes confirm and extend regions of homology between mouse chromosome 13 and human chromosomes 5 and 7, and identify a region of homology between mouse chromosome 13 and human chromosome 6. The molecular genetic linkage map of chromosome 13 provides a framework for establishing linkage relationships between cloned DNA markers and known mouse mutations and for identifying homologous genes in mice and humans that may be involved in disease processes.

Url:
DOI: 10.1016/0888-7543(90)90575-F


Affiliations:


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Le document en format XML

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<term>Gene</term>
<term>Gene order</term>
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<term>Hilda</term>
<term>Hilda probe</term>
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<term>Interspecific backcross analysis</term>
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<term>Molecular markers</term>
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<term>Mouse chromosome</term>
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<term>Mutation</term>
<term>Phenotypic</term>
<term>Probe</term>
<term>Progeny</term>
<term>Proximal region</term>
<term>Receptor</term>
<term>Recombination</term>
<term>Recombination frequencies</term>
<term>Reductase</term>
<term>Rflps</term>
<term>Ribonucleotide reductase</term>
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<term>Somatic cell hybrids</term>
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<div type="abstract" xml:lang="en">Abstract: A molecular genetic linkage map of mouse chromosome 13 was constructed using cloned DNA markers and interspecific backcross mice from two independent crosses. The map locations of Ctla-3, Dhfr, Fim-1, 4 12, Hexb, Hilda, Inhba, Lamb-1.13, Ral, Rrm2-ps3, and Tcrg were determined with respect to the beige (bg) and satin (sa) loci. The map locations of these genes confirm and extend regions of homology between mouse chromosome 13 and human chromosomes 5 and 7, and identify a region of homology between mouse chromosome 13 and human chromosome 6. The molecular genetic linkage map of chromosome 13 provides a framework for establishing linkage relationships between cloned DNA markers and known mouse mutations and for identifying homologous genes in mice and humans that may be involved in disease processes.</div>
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